Ontology highlight
ABSTRACT:
SUBMITTER: Trempe JF
PROVIDER: S-EPMC3630392 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Trempe Jean-François JF Fon Edward A EA
Frontiers in neurology 20130419
Autosomal recessive forms of Parkinson's disease are caused by mutations in three genes: Parkin, PINK1, and DJ-1. These genes encode for proteins with distinct enzymatic activities that may work together to confer neuroprotection. Parkin is an E3 ubiquitin ligase that has been shown to ubiquitinate substrates and to trigger proteasome-dependent degradation or autophagy, two crucial homeostatic processes in neurons. PINK1 is a mitochondrial protein kinase whose activity is required for Parkin-dep ...[more]