Ontology highlight
ABSTRACT:
SUBMITTER: Cao Z
PROVIDER: S-EPMC4672733 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Immunity 20151001 4
CARD9 is a central component of anti-fungal innate immune signaling via C-type lectin receptors, and several immune-related disorders are associated with CARD9 alterations. Here, we used a rare CARD9 variant that confers protection against inflammatory bowel disease as an entry point to investigating CARD9 regulation. We showed that the protective variant of CARD9, which is C-terminally truncated, acted in a dominant-negative manner for CARD9-mediated cytokine production, indicating an important ...[more]