Ontology highlight
ABSTRACT:
SUBMITTER: Chandra D
PROVIDER: S-EPMC7425077 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Chandra Divay D Londino James J Alexander Shaun S Bednash Joseph S JS Zhang Yingze Y Friedlander Robert M RM Daskivich Grant G Carlisle Diane L DL Lariviere William R WR Nakassa Ana Carolina Igami ACI Ross Mark M St Croix Claudette C Nyunoya Toru T Sciurba Frank F Chen Bill B Mallampalli Rama K RK
Journal of molecular and cellular cardiology 20181116
Inflammation is critical in the pathobiology of atherosclerosis. An essential player in the inflammatory process in atherosclerosis are macrophages that scavenge oxidatively modified low-density lipoproteins (OxLDL) deposited in the subendothelium of systemic arteries that secrete a myriad of pro-inflammatory mediators. Here, we identified that a subunit of the Skp-Cullin-F-box ubiquitin E3 ligase apparatus, termed FBXO3, modulates the inflammatory response in atherosclerosis. Specifically, indi ...[more]