Ontology highlight
ABSTRACT:
SUBMITTER: Pascoe HG
PROVIDER: S-EPMC4672773 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Pascoe Heath G HG Gutowski Stephen S Chen Hua H Brautigam Chad A CA Chen Zhe Z Sternweis Paul C PC Zhang Xuewu X
Proceedings of the National Academy of Sciences of the United States of America 20151116 48
PDZ domains are abundant protein interaction modules and typically recognize a short motif at the C terminus of their ligands, with a few residues in the motif endowing the binding specificity. The sequence-based rules, however, cannot fully account for the specificity between the vast number of PDZ domains and ligands in the cell. Plexins are transmembrane receptors that regulate processes such as axon guidance and angiogenesis. Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF ...[more]