Ontology highlight
ABSTRACT:
SUBMITTER: Fujiwara Y
PROVIDER: S-EPMC4353363 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Fujiwara Yoshie Y Goda Natsuko N Tamashiro Tomonari T Narita Hirotaka H Satomura Kaori K Tenno Takeshi T Nakagawa Atsushi A Oda Masayuki M Suzuki Mamoru M Sakisaka Toshiaki T Takai Yoshimi Y Hiroaki Hidekazu H
Protein science : a publication of the Protein Society 20150113 3
Afadin, a scaffold protein localized in adherens junctions (AJs), links nectins to the actin cytoskeleton. Nectins are the major cell adhesion molecules of AJs. At the initial stage of cell-cell junction formation, the nectin-afadin interaction plays an indispensable role in AJ biogenesis via recruiting and tethering other components. The afadin PDZ domain (AFPDZ) is responsible for binding the cytoplasmic C-terminus of nectins. AFPDZ is a class II PDZ domain member, which prefers ligands contai ...[more]