Ontology highlight
ABSTRACT:
SUBMITTER: Zhang ET
PROVIDER: S-EPMC4672820 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Zhang Elisa T ET He Yuan Y Grob Patricia P Fong Yick W YW Nogales Eva E Tjian Robert R
Proceedings of the National Academy of Sciences of the United States of America 20151116 48
The Xeroderma pigmentosum complementation group C (XPC) complex is a versatile factor involved in both nucleotide excision repair and transcriptional coactivation as a critical component of the NANOG, OCT4, and SOX2 pluripotency gene regulatory network. Here we present the structure of the human holo-XPC complex determined by single-particle electron microscopy to reveal a flexible, ear-shaped structure that undergoes localized loss of order upon DNA binding. We also determined the structure of ...[more]