Functional and Mechanistic Studies of XPC DNA-Repair Complex as Transcriptional Coactivator in Embryonic Stem Cells
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ABSTRACT: We recently identified the DNA repair complex XPC-RAD23B-CETN2 as a stem cell coactivator (SCC) required for OCT4 and SOX2 transcriptional activation. Here we investigate genome-wide the role of SCC in murine ESCs by mapping regions bound by its RAD23B subunit in wild type and Xpc-/- ESCs, and analyzing transcriptional profiles of SCC-depleted ESCs.
ORGANISM(S): Mus musculus
PROVIDER: GSE64040 | GEO | 2015/04/20
SECONDARY ACCESSION(S): PRJNA269957
REPOSITORIES: GEO
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