Ontology highlight
ABSTRACT:
SUBMITTER: Faria CC
PROVIDER: S-EPMC4673298 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Faria Claudia C CC Agnihotri Sameer S Mack Stephen C SC Golbourn Brian J BJ Diaz Roberto J RJ Olsen Samantha S Bryant Melissa M Bebenek Matthew M Wang Xin X Bertrand Kelsey C KC Kushida Michelle M Head Renee R Clark Ian I Dirks Peter P Smith Christian A CA Taylor Michael D MD Rutka James T JT
Oncotarget 20150801 25
Advances in the molecular biology of medulloblastoma revealed four genetically and clinically distinct subgroups. Group 3 medulloblastomas are characterized by frequent amplifications of the oncogene MYC, a high incidence of metastasis, and poor prognosis despite aggressive therapy. We investigated several potential small molecule inhibitors to target Group 3 medulloblastomas based on gene expression data using an in silico drug screen. The Connectivity Map (C-MAP) analysis identified piperlongu ...[more]