Ontology highlight
ABSTRACT:
SUBMITTER: Mullarky E
PROVIDER: S-EPMC4763784 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Mullarky Edouard E Lucki Natasha C NC Beheshti Zavareh Reza R Anglin Justin L JL Gomes Ana P AP Nicolay Brandon N BN Wong Jenny C Y JC Christen Stefan S Takahashi Hidenori H Singh Pradeep K PK Blenis John J Warren J David JD Fendt Sarah-Maria SM Asara John M JM DeNicola Gina M GM Lyssiotis Costas A CA Lairson Luke L LL Cantley Lewis C LC
Proceedings of the National Academy of Sciences of the United States of America 20160201 7
Cancer cells reprogram their metabolism to promote growth and proliferation. The genetic evidence pointing to the importance of the amino acid serine in tumorigenesis is striking. The gene encoding the enzyme 3-phosphoglycerate dehydrogenase (PHGDH), which catalyzes the first committed step of serine biosynthesis, is overexpressed in tumors and cancer cell lines via focal amplification and nuclear factor erythroid-2-related factor 2 (NRF2)-mediated up-regulation. PHGDH-overexpressing cells are e ...[more]