Vasculogenic dynamics in 3D engineered tissue constructs.
Ontology highlight
ABSTRACT:
SUBMITTER: Blinder YJ
PROVIDER: S-EPMC4673462 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Publications
Vasculogenic dynamics in 3D engineered tissue constructs.
Blinder Yaron J YJ Freiman Alina A Raindel Noa N Mooney David J DJ Levenberg Shulamit S
Scientific reports 20151209
Implantable 3D engineered vascular tissue constructs can be formed by co-culturing endothelial and fibroblast cells on macroporous scaffolds. Here we show that these constructs can be used for studying the dynamics of neovascular formation in-vitro by a combination of live confocal imaging and an array of image processing and analysis tools, revealing multiple distinct stages of morphogenesis. We show that this process involves both vasculogenic and angiogenic elements, including an initial endo ...[more]
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