Quantification of plasma microRNAs in a group of healthy smokers, ex-smokers and non-smokers and correlation to biomarkers of tobacco exposure.
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ABSTRACT:
SUBMITTER: Banerjee A
PROVIDER: S-EPMC4673588 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
Quantification of plasma microRNAs in a group of healthy smokers, ex-smokers and non-smokers and correlation to biomarkers of tobacco exposure.
Banerjee Anisha A Waters David D Camacho Oscar M OM Minet Emmanuel E
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20150119 2
The stability of circulating miRNAs, their non-invasive sampling techniques and deregulation in diseases make them potential candidate biomarkers of biological effect. Here, we profiled the level of 84 plasma miRNAs in 30 smokers, 20 non-smokers and 20 ex-smokers. A robust statistical strategy was applied with replicate samples to account for reproducibility of the results. We identified differential expression of miR-124 and let-7a between the smoking and control groups. We further explored the ...[more]
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