Ontology highlight
ABSTRACT:
SUBMITTER: Haetscher N
PROVIDER: S-EPMC4674773 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Haetscher Nadine N Feuermann Yonatan Y Wingert Susanne S Rehage Maike M Thalheimer Frederic B FB Weiser Christian C Bohnenberger Hanibal H Jung Klaus K Schroeder Timm T Serve Hubert H Oellerich Thomas T Hennighausen Lothar L Rieger Michael A MA
Nature communications 20151125
Haematopoietic stem cells (HSCs) require the right composition of microRNAs (miR) for proper life-long balanced blood regeneration. Here we show a regulatory circuit that prevents excessive HSC self-renewal by upregulation of miR-193b upon self-renewal promoting thrombopoietin (TPO)-MPL-STAT5 signalling. In turn, miR-193b restricts cytokine signalling, by targeting the receptor tyrosine kinase c-KIT. We generated a miR-193b knockout mouse model to unravel the physiological function of miR-193b i ...[more]