Ontology highlight
ABSTRACT:
SUBMITTER: Avila AI
PROVIDER: S-EPMC5291257 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Avila Alush I AI Illing Anett A Becker Friedrich F Maerz Lars D LD Morita Yohei Y Philipp Melanie M Burkhalter Martin D MD
Nucleic acids research 20160502 13
Reduced capacity of genome maintenance represents a problem for any organism, potentially causing premature death, carcinogenesis, or accelerated ageing. Strikingly though, loss of certain genome stability factors can be beneficial, especially for the maintenance of tissue stem cells of the intestine and the haematopoietic system. We therefore screened for genome stability factors negatively impacting maintenance of haematopoietic stem cells (HSC) in the context of ionising radiation (IR). We fo ...[more]