The Influence of Crowding Conditions on the Thermodynamic Feasibility of Metabolic Pathways.
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ABSTRACT:
SUBMITTER: Angeles-Martinez L
PROVIDER: S-EPMC4675822 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Publications
The Influence of Crowding Conditions on the Thermodynamic Feasibility of Metabolic Pathways.
Angeles-Martinez Liliana L Theodoropoulos Constantinos C
Biophysical journal 20151201 11
Intracellular reactions are carried out in a crowded medium where the macromolecules occupy ∼40% of the total volume. This decrease in the available volume affects the activity of the reactants. Scaled particle theory is used for the estimation of the activity coefficients of the metabolites, and thereby for the assessment of the impact of the presence of background molecules, on the estimation of the Gibbs free energy change (ΔrG) of the reactions. The lactic acid pathway and the central carbon ...[more]
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