Ontology highlight
ABSTRACT:
SUBMITTER: Zhang R
PROVIDER: S-EPMC4676544 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Zhang Rou R Suwanarusk Rossarin R Malleret Benoit B Cooke Brian M BM Nosten Francois F Lau Yee-Ling YL Dao Ming M Lim Chwee Teck CT Renia Laurent L Tan Kevin Shyong Wei KS Russell Bruce B
The Journal of infectious diseases 20150701 1
Recent clinical trials revealed a surprisingly rapid clearance of red blood cells (RBCs) infected with malaria parasites by the spiroindolone KAE609. Here, we show that ring-stage parasite-infected RBCs exposed to KAE609 become spherical and rigid, probably through osmotic dysregulation consequent to the disruption of the parasite's sodium efflux pump (adenosine triphosphate 4). We also show that this peculiar drug effect is likely to cause accelerated splenic clearance of the rheologically impa ...[more]