Ontology highlight
ABSTRACT:
SUBMITTER: Douglass AN
PROVIDER: S-EPMC4427874 | biostudies-other | 2015 May
REPOSITORIES: biostudies-other
Douglass Alyse N AN Kain Heather S HS Abdullahi Marian M Arang Nadia N Austin Laura S LS Mikolajczak Sebastian A SA Billman Zachary P ZP Hume Jen C C JCC Murphy Sean C SC Kappe Stefan H I SHI Kaushansky Alexis A
Molecular therapy : the journal of the American Society of Gene Therapy 20150204 5
Eliminating malaria parasites during the asymptomatic but obligate liver stages (LSs) of infection would stop disease and subsequent transmission. Unfortunately, only a single licensed drug that targets all LSs, Primaquine, is available. Targeting host proteins might significantly expand the repertoire of prophylactic drugs against malaria. Here, we demonstrate that both Bcl-2 inhibitors and P53 agonists dramatically reduce LS burden in a mouse malaria model in vitro and in vivo by altering the ...[more]