A new quorum-sensing system (TprA/PhrA) for Streptococcus pneumoniae?D39 that regulates a lantibiotic biosynthesis gene cluster.
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ABSTRACT:
SUBMITTER: Hoover SE
PROVIDER: S-EPMC4676566 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
A new quorum-sensing system (TprA/PhrA) for Streptococcus pneumoniae D39 that regulates a lantibiotic biosynthesis gene cluster.
Hoover Sharon E SE Perez Amilcar J AJ Tsui Ho-Ching T HC Sinha Dhriti D Smiley David L DL DiMarchi Richard D RD Winkler Malcolm E ME Lazazzera Beth A BA
Molecular microbiology 20150526 2
The Phr peptides of the Bacillus species mediate quorum sensing, but their identification and function in other species of bacteria have not been determined. We have identified a Phr peptide quorum-sensing system (TprA/PhrA) that controls the expression of a lantibiotic gene cluster in the Gram-positive human pathogen, Streptococcus pneumoniae. Lantibiotics are highly modified peptides that are part of the bacteriocin family of antimicrobial peptides. We have characterized the basic mechanism fo ...[more]
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