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Lack of association between the CARD10 rs6000782 polymorphism and type 1 autoimmune hepatitis in a Japanese population.


ABSTRACT: Previous genome-wide association studies have evaluated the impact of common genetic variants and identified several non-HLA risk loci associated with autoimmune liver diseases. More recent genome-wide association studies and replication analyses reported an association between variants of the CARD10 polymorphism rs6000782 and risk of type 1 autoimmune hepatitis (AIH). In this case-control study, we genotyped 326 Japanese AIH patients and 214 control subjects.Genomic DNA from 540 individuals of Japanese origin, including 326 patients with type-1 AIH and 214 healthy controls, was analyzed for two single nucleotide polymorphisms (SNPs) in the CARD10 gene. We selected CARD10 rs6000782 SNPs and genotyped these using PCR-RFLP method and direct sequencing. The Chi square test revealed that the rs6000782 variant alle (c) was not associated with the susceptibility for AIH in a Japanese population [p = 0.376, odds ratio (OR) 1.271, 95 % confidence interval (CI) 0.747-2.161] in an allele model. Our data also showed that CARD10 rs6000782 variants were not associated with AIH or with the clinical parameters of AIH.In this study we examined an association between rs6000782 SNPs in the CARD10 gene and type-1 AIH. Results showed no significant association of rs62000782 with type-1 AIH in a Japanese population. This study demonstrated no association between CARD10 rs6000782 variants and AIH in a Japanese population.

SUBMITTER: Migita K 

PROVIDER: S-EPMC4677039 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Lack of association between the CARD10 rs6000782 polymorphism and type 1 autoimmune hepatitis in a Japanese population.

Migita Kiyoshi K   Jiuchi Yuka Y   Furukawa Hiroshi H   Nakamura Minoru M   Komori Atsumasa A   Yasunami Michio M   Kozuru Hideko H   Abiru Seigo S   Yamasaki Kazumi K   Nagaoka Shinya S   Hashimoto Satoru S   Bekki Shigemune S   Yoshizawa Kaname K   Shimada Masaaki M   Kouno Hiroshi H   Kamitsukasa Hiroshi H   Komatsu Tatsuji T   Hijioka Taizo T   Nakamuta Makoto M   Naganuma Atsushi A   Yamashita Haruhiro H   Nishimura Hideo H   Ohta Hajime H   Nakamura Yoko Y   Ario Keisuke K   Oohara Yukio Y   Sugi Kazuhiro K   Tomizawa Minoru M   Sato Takeaki T   Takahashi Hironao H   Muro Toyokichi T   Makita Fujio F   Mita Eiji E   Sakai Hironori H   Yatsuhashi Hiroshi H  

BMC research notes 20151212


<h4>Background</h4>Previous genome-wide association studies have evaluated the impact of common genetic variants and identified several non-HLA risk loci associated with autoimmune liver diseases. More recent genome-wide association studies and replication analyses reported an association between variants of the CARD10 polymorphism rs6000782 and risk of type 1 autoimmune hepatitis (AIH). In this case-control study, we genotyped 326 Japanese AIH patients and 214 control subjects.<h4>Results</h4>G  ...[more]

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