Ontology highlight
ABSTRACT:
SUBMITTER: Lao PJ
PROVIDER: S-EPMC4677061 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Alzheimer's & dementia : the journal of the Alzheimer's Association 20150613 4
<h4>Introduction</h4>In Down syndrome (DS), the overproduction of amyloid precursor protein is hypothesized to predispose young adults to early expression of Alzheimer-like neuropathology.<h4>Methods</h4>PET imaging with carbon 11-labeled Pittsburgh compound B examined the pattern of amyloid-β deposition in 68 nondemented adults with DS (30-53 years) to determine the relationship between deposition and normal aging. Standard uptake value ratio (SUVR) images were created with cerebellar gray matt ...[more]