Ontology highlight
ABSTRACT:
SUBMITTER: Vlassenko AG
PROVIDER: S-EPMC3243969 | biostudies-other | 2011 Nov
REPOSITORIES: biostudies-other
Annals of neurology 20111101 5
Amyloid-beta (Aβ) accumulation was evaluated with 2 [(11)C]Pittsburgh compound B (PiB) positron emission tomography scans about 2.5 years apart in 146 cognitively normal adults. Seventeen of 21 participants with initially elevated Aβ deposition demonstrated subsequent Aβ plaque growth (approximately 8.0% per year), and none reverted to a state of no Aβ deposits. Ten individuals converted from negative to positive PiB status, based on a threshold of the mean cortical binding potential, representi ...[more]