Amyloid-beta plaque growth in cognitively normal adults: longitudinal [11C]Pittsburgh compound B data.
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ABSTRACT:
SUBMITTER: Vlassenko AG
PROVIDER: S-EPMC3243969 | biostudies-other | 2011 Nov
REPOSITORIES: biostudies-other
Publications
Amyloid-beta plaque growth in cognitively normal adults: longitudinal [11C]Pittsburgh compound B data.
Vlassenko Andrei G AG Mintun Mark A MA Xiong Chengjie C Sheline Yvette I YI Goate Alison M AM Benzinger Tammie L S TL Morris John C JC
Annals of neurology 20111101 5
Amyloid-beta (Aβ) accumulation was evaluated with 2 [(11)C]Pittsburgh compound B (PiB) positron emission tomography scans about 2.5 years apart in 146 cognitively normal adults. Seventeen of 21 participants with initially elevated Aβ deposition demonstrated subsequent Aβ plaque growth (approximately 8.0% per year), and none reverted to a state of no Aβ deposits. Ten individuals converted from negative to positive PiB status, based on a threshold of the mean cortical binding potential, representi ...[more]
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