Multimode fibre: Light-sheet microscopy at the tip of a needle.
Ontology highlight
ABSTRACT:
SUBMITTER: Ploschner M
PROVIDER: S-EPMC4677299 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Publications
Multimode fibre: Light-sheet microscopy at the tip of a needle.
Plöschner Martin M Kollárová Věra V Dostál Zbyněk Z Nylk Jonathan J Barton-Owen Thomas T Ferrier David E K DE Chmelík Radim R Dholakia Kishan K Čižmár Tomáš T
Scientific reports 20151214
Light-sheet fluorescence microscopy has emerged as a powerful platform for 3-D volumetric imaging in the life sciences. Here, we introduce an important step towards its use deep inside biological tissue. Our new technique, based on digital holography, enables delivery of the light-sheet through a multimode optical fibre--an optical element with extremely small footprint, yet permitting complex control of light transport processes within. We show that this approach supports some of the most advan ...[more]
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