Ontology highlight
ABSTRACT:
SUBMITTER: Ishii K
PROVIDER: S-EPMC4677347 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Ishii Kentaro K Noda Masanori M Yagi Hirokazu H Thammaporn Ratsupa R Seetaha Supaporn S Satoh Tadashi T Kato Koichi K Uchiyama Susumu S
Scientific reports 20151214
The 20S core particle of the eukaryotic proteasome is composed of two α- and two β-rings, each of which is a hetero-heptamer composed of seven homologous but distinct subunits. Although formation of the eukaryotic proteasome is a highly ordered process assisted by assembly chaperones, α7, an α-ring component, has the unique property of self-assembling into a homo-tetradecamer. We used biophysical methods to characterize the oligomeric states of this proteasome subunit and its interaction with α6 ...[more]