Ontology highlight
ABSTRACT:
SUBMITTER: Hay D
PROVIDER: S-EPMC4678575 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
MedChemComm 20130101 1
Simple 1-substituted 5- and 6-isoxazolyl-benzimidazoles have been shown to be potent inhibitors of the BET bromodomains with selectivity over the related bromodomain of CBP. The reported inhibitors were prepared from simple starting materials in two steps followed by separation of the regioisomers or regioselectively in three steps. ...[more]