Ontology highlight
ABSTRACT:
SUBMITTER: Tagua VG
PROVIDER: S-EPMC4679004 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Tagua Victor G VG Pausch Marcell M Eckel Maike M Gutiérrez Gabriel G Miralles-Durán Alejandro A Sanz Catalina C Eslava Arturo P AP Pokorny Richard R Corrochano Luis M LM Batschauer Alfred A
Proceedings of the National Academy of Sciences of the United States of America 20151117 49
DASH (Drosophila, Arabidopsis, Synechocystis, Human)-type cryptochromes (cry-DASH) belong to a family of flavoproteins acting as repair enzymes for UV-B-induced DNA lesions (photolyases) or as UV-A/blue light photoreceptors (cryptochromes). They are present in plants, bacteria, various vertebrates, and fungi and were originally considered as sensory photoreceptors because of their incapability to repair cyclobutane pyrimidine dimer (CPD) lesions in duplex DNA. However, cry-DASH can repair CPDs i ...[more]