Ontology highlight
ABSTRACT:
SUBMITTER: Bebu I
PROVIDER: S-EPMC4679075 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Biostatistics (Oxford, England) 20150908 1
Composite outcomes are common in clinical trials, especially for multiple time-to-event outcomes (endpoints). The standard approach that uses the time to the first outcome event has important limitations. Several alternative approaches have been proposed to compare treatment versus control, including the proportion in favor of treatment and the win ratio. Herein, we construct tests of significance and confidence intervals in the context of composite outcomes based on prioritized components using ...[more]