Weighted win loss approach for analyzing prioritized outcomes.
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ABSTRACT:
SUBMITTER: Luo X
PROVIDER: S-EPMC5490500 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Weighted win loss approach for analyzing prioritized outcomes.
Luo Xiaodong X Qiu Junshan J Bai Steven S Tian Hong H
Statistics in medicine 20170326 15
To analyze prioritized outcomes, Buyse (2010) and Pocock et al. (2012) proposed the win loss approach. In this paper, we first study the relationship between the win loss approach and the traditional survival analysis on the time to the first event. We then propose the weighted win loss statistics to improve the efficiency of the unweighted methods. A closed-form variance estimator of the weighted win loss statistics is derived to facilitate hypothesis testing and study design. We also calculate ...[more]
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