Ontology highlight
ABSTRACT:
SUBMITTER: Vevea JD
PROVIDER: S-EPMC4679156 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Vevea Jason D JD Garcia Enrique J EJ Chan Robin B RB Zhou Bowen B Schultz Mei M Di Paolo Gilbert G McCaffery J Michael JM Pon Liza A LA
Developmental cell 20151201 5
The immediate responses to inhibition of phosphatidylcholine (PC) biosynthesis in yeast are altered phospholipid levels, slow growth, and defects in the morphology and localization of ER and mitochondria. With chronic lipid imbalance, yeast adapt. Lipid droplet (LD) biogenesis and conversion of phospholipids to triacylglycerol are required for restoring some phospholipids to near-wild-type levels. We confirmed that the unfolded protein response is activated by this lipid stress and find that Hsp ...[more]