Ontology highlight
ABSTRACT:
SUBMITTER: Kassan A
PROVIDER: S-EPMC3871434 | biostudies-other | 2013 Dec
REPOSITORIES: biostudies-other
Kassan Adam A Herms Albert A Fernández-Vidal Andrea A Bosch Marta M Schieber Nicole L NL Reddy Babu J N BJ Fajardo Alba A Gelabert-Baldrich Mariona M Tebar Francesc F Enrich Carlos C Gross Steven P SP Parton Robert G RG Pol Albert A
The Journal of cell biology 20131201 6
Control of lipid droplet (LD) nucleation and copy number are critical, yet poorly understood, processes. We use model peptides that shift from the endoplasmic reticulum (ER) to LDs in response to fatty acids to characterize the initial steps of LD formation occurring in lipid-starved cells. Initially, arriving lipids are rapidly packed in LDs that are resistant to starvation (pre-LDs). Pre-LDs are restricted ER microdomains with a stable core of neutral lipids. Subsequently, a first round of "em ...[more]