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Croconaine rotaxane for acid activated photothermal heating and ratiometric photoacoustic imaging of acidic pH.

ABSTRACT: Absorption of 808 nm laser light by liposomes containing a pH sensitive, near-infrared croconaine rotaxane dye increases dramatically in weak acid. A stealth liposome composition permits acid activated, photothermal heating and also acts as an effective nanoparticle probe for ratiometric photoacoustic imaging of acidic pH in deep sample locations, including a living mouse.

SUBMITTER: Guha S

PROVIDER: S-EPMC4679412 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Croconaine rotaxane for acid activated photothermal heating and ratiometric photoacoustic imaging of acidic pH.

Guha Samit S Shaw Gillian Karen GK Mitcham Trevor M TM Bouchard Richard R RR Smith Bradley D BD

Chemical communications (Cambridge, England) 20160101 1

Absorption of 808 nm laser light by liposomes containing a pH sensitive, near-infrared croconaine rotaxane dye increases dramatically in weak acid. A stealth liposome composition permits acid activated, photothermal heating and also acts as an effective nanoparticle probe for ratiometric photoacoustic imaging of acidic pH in deep sample locations, including a living mouse. ...[more]

PMID: 26502996

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