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Ratiometric Photoacoustic Molecular Imaging for Methylmercury Detection in Living Subjects.


ABSTRACT: Photoacoustic molecular imaging is an emerging and promising diagnostic tool for heavy metal ions detection. Methylmercury (MeHg+ ) is one of the most potent neurotoxins, which damages the brain and nervous system of human beings through fish consumption. The development of a selective and sensitive method for MeHg+ detection is highly desirable. In this Communication, we develope a chemoselective photoacoustic sensor (LP-hCy7) composed of the liposome (LP) and MeHg+ -responsive near-infrared (NIR) cyanine dye (hCy7) for MeHg+ detection within living subjects, such as zebrafish and mouse. The as-prepared LP-hCy7 nanoprobe displays unique dual-shift NIR absorbance peaks and produces a normalized turn-on response after the reaction of MeHg+ and hCy7 through a mercury-promoted cyclization reaction. The absorbance intensities of LP-hCy7 nanoprobe at 690 and 860 nm are decreased and increased, respectively. The ratiometric photoacoustic signal (PA860/PA690) is noticeably increased in the presence of MeHg+ . These findings not only provide a ratiometric photoacoustic molecular imaging probe for the detection of metal ions in vivo, but also provides a tool for spectroscopic photoacoustic molecular imaging.

SUBMITTER: Liu Y 

PROVIDER: S-EPMC5553071 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Ratiometric Photoacoustic Molecular Imaging for Methylmercury Detection in Living Subjects.

Liu Yi Y   Wang Sheng S   Ma Ying Y   Lin Jing J   Wang Hai-Yan HY   Gu Yueqing Y   Chen Xiaoyuan X   Huang Peng P  

Advanced materials (Deerfield Beach, Fla.) 20170222 17


Photoacoustic molecular imaging is an emerging and promising diagnostic tool for heavy metal ions detection. Methylmercury (MeHg<sup>+</sup> ) is one of the most potent neurotoxins, which damages the brain and nervous system of human beings through fish consumption. The development of a selective and sensitive method for MeHg<sup>+</sup> detection is highly desirable. In this Communication, we develope a chemoselective photoacoustic sensor (LP-hCy7) composed of the liposome (LP) and MeHg<sup>+</  ...[more]

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