Ontology highlight
ABSTRACT:
SUBMITTER: Habte HH
PROVIDER: S-EPMC4679429 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Habte Habtom H HH Banerjee Saikat S Shi Heliang H Qin Yali Y Cho Michael W MW
Virology 20151009
The membrane-proximal external region (MPER) of HIV-1 gp41 is an attractive target for vaccine development. Thus, better understanding of its immunogenic properties in various structural contexts is important. We previously described the crystal structure of a trimeric protein complex named gp41-HR1-54Q, which consists of the heptad repeat regions 1 and 2 and the MPER. The protein was efficiently recognized by broadly neutralizing antibodies. Here, we describe its immunogenic properties in rabbi ...[more]