Ontology highlight
ABSTRACT:
SUBMITTER: Ivankin A
PROVIDER: S-EPMC8796276 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Ivankin Andrey A Apellániz Beatriz B Gidalevitz David D Nieva José L JL
Biochimica et biophysica acta 20120609 11
Membrane-activity of the glycoprotein 41 membrane-proximal external region (MPER) is required for HIV-1 membrane fusion. Consequently, its inhibition results in viral neutralization by the antibody 4E10. Previous studies suggested that MPER might act during fusion by locally perturbing the viral membrane, i.e., following a mechanism similar to that proposed for certain antimicrobial peptides. Here, we explore the molecular mechanism of how MPER permeates lipid monolayers containing cholesterol, ...[more]