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Asymmetric synthesis of 1H-pyrrol-3(2H)-ones from 2,3-diketoesters by combination of aldol condensation with benzilic acid rearrangement.

ABSTRACT: An efficient two-step protocol for the asymmetric synthesis of 1H-pyrrol-3(2H)-one derivatives in 99% ee from conveniently accessed 2,3-diketoesters has been developed.

SUBMITTER: Sha Q

PROVIDER: S-EPMC4679521 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Asymmetric synthesis of 1H-pyrrol-3(2H)-ones from 2,3-diketoesters by combination of aldol condensation with benzilic acid rearrangement.

Sha Qiang Q Arman Hadi H Doyle Michael P MP

Chemical communications (Cambridge, England) 20160101 1

An efficient two-step protocol for the asymmetric synthesis of 1H-pyrrol-3(2H)-one derivatives in 99% ee from conveniently accessed 2,3-diketoesters has been developed. ...[more]

PMID: 26498040

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