Dataset Information
Asymmetric Aldol Reaction of 3-Acetyl-2H-chromen-2-ones and Isatins Catalyzed by a Bifunctional Quinidine Urea Catalyst.
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ABSTRACT:
SUBMITTER: Abbaraju S
PROVIDER: S-EPMC4019438 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Publications
Asymmetric Aldol Reaction of 3-Acetyl-2<i>H</i>-chromen-2-ones and Isatins Catalyzed by a Bifunctional Quinidine Urea Catalyst.
Advanced synthesis & catalysis 20140101 1
The asymmetric aldol reaction of 3-acetyl-2<i>H</i>-chromen-2-ones and isatins has been realized by using a bifunctional quinidine-derived urea as the catalyst. The corresponding 3-hydroxyoxindole derivatives containing a 2<i>H</i>-chromen-2-one moiety were obtained in good yields and high enantioselectivities. When (<i>Z</i>)-ethyl 2-benzylideneacetoacetate was used as the substrate, a mixture of two diastereomers (both <i>Z</i> and <i>E</i>) was obtained due to the isomerization of the double ...[more]