Unknown

Dataset Information

0

Evaluation of a Live-Attenuated Human Parainfluenza Type 1 Vaccine in Adults and Children.

ABSTRACT: We conducted a phase I clinical trial (clinicaltrials.gov identifier, NCT00641017) of the experimental live-attenuated human parainfluenza virus type 1 (HPIV-1) vaccine rHPIV-1/84/del 170/942A sequentially in 3 groups: adults, HPIV-1-seropositive children, and HPIV-1-seronegative children, the target population for vaccination. rHPIV-1/84/del 170/942A was appropriately restricted in replication in adults and HPIV-1-seropositive children but was overattenuated (ie, insufficiently infectious and immunogenic) for HPIV-1-seronegative children.

SUBMITTER: Karron RA 

PROVIDER: S-EPMC4681387 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Evaluation of a Live-Attenuated Human Parainfluenza Type 1 Vaccine in Adults and Children.

Karron Ruth A RA   San Mateo Jocelyn J   Thumar Bhagvanji B   Schaap-Nutt Anne A   Buchholz Ursula J UJ   Schmidt Alexander C AC   Bartlett Emmalene J EJ   Murphy Brian R BR   Collins Peter L PL  

Journal of the Pediatric Infectious Diseases Society 20141112 4

We conducted a phase I clinical trial (clinicaltrials.gov identifier, NCT00641017) of the experimental live-attenuated human parainfluenza virus type 1 (HPIV-1) vaccine rHPIV-1/84/del 170/942A sequentially in 3 groups: adults, HPIV-1-seropositive children, and HPIV-1-seronegative children, the target population for vaccination. rHPIV-1/84/del 170/942A was appropriately restricted in replication in adults and HPIV-1-seropositive children but was overattenuated (ie, insufficiently infectious and i  ...[more]

Similar Datasets

Unknown Evaluation of a Live Attenuated Human Metapneumovirus Vaccine in Adults and Children.
| S-EPMC6075531 | biostudies-literature
Unknown Safety and infectivity of two doses of live-attenuated recombinant cold-passaged human parainfluenza type 3 virus vaccine rHPIV3cp45 in HPIV3-seronegative young children.
| S-EPMC3889708 | biostudies-literature
Transcriptomics Mucosal immune responses to live attenuated influenza vaccine in young adults
2023-10-19 | GSE230494 | GEO
Transcriptomics Whole blood RNAseq following live attenuated influenza vaccine in Gambian children
2019-03-14 | GSE128224 | GEO
Unknown A novel human parainfluenza virus type 1 (HPIV1) with separated P and C genes is useful for generating C gene mutants for evaluation as live-attenuated virus vaccine candidates.
| S-EPMC2791187 | biostudies-literature
Unknown Expression of the surface glycoproteins of human parainfluenza virus type 3 by bovine parainfluenza virus type 3, a novel attenuated virus vaccine vector.
| S-EPMC112444 | biostudies-literature
Unknown Evaluation of efficacy and effectiveness of live attenuated zoster vaccine.
| S-EPMC4718315 | biostudies-other
Unknown Growth restriction of an experimental live attenuated human parainfluenza virus type 2 vaccine in human ciliated airway epithelium in vitro parallels attenuation in African green monkeys.
| S-EPMC2844349 | biostudies-literature
Transcriptomics RNAseq from nasopharyngeal swab RNA prior to intranasal live attenuated influenza vaccine in children
2020-10-23 | GSE159884 | GEO
Unknown Evaluation of a Live Attenuated S. sonnei Vaccine Strain in the Human Enteroid Model.
| S-EPMC8468197 | biostudies-literature