Ontology highlight
ABSTRACT:
SUBMITTER: Drickamer K
PROVIDER: S-EPMC4681411 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Drickamer Kurt K Taylor Maureen E ME
Current opinion in structural biology 20150707
The majority of the C-type lectin-like domains in the human genome likely to bind sugars have been investigated structurally, although novel mechanisms of sugar binding are still being discovered. In the immune system, adhesion and endocytic receptors that bind endogenous mammalian glycans are often conserved, while pathogen-binding C-type lectins on cells of the innate immune system are more divergent. Lack of orthology between some human and mouse receptors, as well as overlapping specificitie ...[more]