Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC4681442 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Li Jie J Kuang Yi Y Shi Junfeng J Zhou Jie J Medina Jamie E JE Zhou Rong R Yuan Dan D Yang Cuihong C Wang Huaimin H Yang Zhimou Z Liu Jianfeng J Dinulescu Daniela M DM Xu Bing B
Angewandte Chemie (International ed. in English) 20150914 45
Anticancer drug resistance demands innovative approaches that boost the activity of drugs against drug-resistant cancers without increasing the systemic toxicity. Here we show the use of enzyme-instructed self-assembly (EISA) to generate intracellular supramolecular assemblies that drastically boost the activity of cisplatin against drug-resistant ovarian cancer cells. We design and synthesize small peptide precursors as the substrates of carboxylesterase (CES). CES cleaves the ester bond pre-in ...[more]