Ontology highlight
ABSTRACT:
SUBMITTER: Davidson LA
PROVIDER: S-EPMC4681667 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Davidson Laurie A LA Callaway Evelyn S ES Kim Eunjoo E Weeks Brad R BR Fan Yang-Yi YY Allred Clinton D CD Chapkin Robert S RS
Cancer research 20151202 24
p53 has been shown to mediate cancer stem-like cell function by suppressing pluripotency and cellular dedifferentiation. However, there have been no studies to date that have addressed the specific effects of p53 loss in colonic adult stem cells. In this study, we investigated the consequences of conditionally ablating p53 in the highly relevant Lgr5(+) stem cell population on tumor initiation and progression in the colon. In a mouse model of carcinogen (AOM)-induced colon cancer, tamoxifen-indu ...[more]