Ontology highlight
ABSTRACT:
SUBMITTER: Wu K
PROVIDER: S-EPMC4682110 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Nature communications 20151209
The landscape of genetic alterations in lung adenocarcinoma derived from Asian patients is largely uncharacterized. Here we present an integrated genomic and transcriptomic analysis of 335 primary lung adenocarcinomas and 35 corresponding lymph node metastases from Chinese patients. Altogether 13 significantly mutated genes are identified, including the most commonly mutated gene TP53 and novel mutation targets such as RHPN2, GLI3 and MRC2. TP53 mutations are furthermore significantly enriched i ...[more]