Ontology highlight
ABSTRACT:
SUBMITTER: Peng L
PROVIDER: S-EPMC5355282 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Peng Lihua L Lee Leo J LJ Xiong Heng H Su Hong H Rao Junhua J Xiao Dakai D He Jianxing J Wu Kui K Liu Dongbing D
Oncotarget 20170201 7
RNA editing results in post-transcriptional modification and could potentially contribute to carcinogenesis. However, RNA editing in advanced lung adenocarcinomas has not yet been studied. Based on whole genome and transcriptome sequencing data, we identified 1,071,296 RNA editing events from matched normal, primary and metastatic samples contributed by 24 lung adenocarcinoma patients, with 91.3% A-to-G editing on average, and found significantly more RNA editing sites in tumors than in normal s ...[more]