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Long-term neural and physiological phenotyping of a single human.

ABSTRACT: Psychiatric disorders are characterized by major fluctuations in psychological function over the course of weeks and months, but the dynamic characteristics of brain function over this timescale in healthy individuals are unknown. Here, as a proof of concept to address this question, we present the MyConnectome project. An intensive phenome-wide assessment of a single human was performed over a period of 18 months, including functional and structural brain connectivity using magnetic resonance imaging, psychological function and physical health, gene expression and metabolomics. A reproducible analysis workflow is provided, along with open access to the data and an online browser for results. We demonstrate dynamic changes in brain connectivity over the timescales of days to months, and relations between brain connectivity, gene expression and metabolites. This resource can serve as a testbed to study the joint dynamics of human brain and metabolic function over time, an approach that is critical for the development of precision medicine strategies for brain disorders.

SUBMITTER: Poldrack RA

PROVIDER: S-EPMC4682164 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Publications

Long-term neural and physiological phenotyping of a single human.

Poldrack Russell A RA Laumann Timothy O TO Koyejo Oluwasanmi O Gregory Brenda B Hover Ashleigh A Chen Mei-Yen MY Gorgolewski Krzysztof J KJ Luci Jeffrey J Joo Sung Jun SJ Boyd Ryan L RL Hunicke-Smith Scott S Simpson Zack Booth ZB Caven Thomas T Sochat Vanessa V Shine James M JM Gordon Evan E Snyder Abraham Z AZ Adeyemo Babatunde B Petersen Steven E SE Glahn David C DC Reese Mckay D D Curran Joanne E JE Göring Harald H H HH Carless Melanie A MA Blangero John J Dougherty Robert R Leemans Alexander A Handwerker Daniel A DA Frick Laurie L Marcotte Edward M EM Mumford Jeanette A JA

Nature communications 20151209

Psychiatric disorders are characterized by major fluctuations in psychological function over the course of weeks and months, but the dynamic characteristics of brain function over this timescale in healthy individuals are unknown. Here, as a proof of concept to address this question, we present the MyConnectome project. An intensive phenome-wide assessment of a single human was performed over a period of 18 months, including functional and structural brain connectivity using magnetic resonance i ...[more]

PMID: 26648521

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Project description:The dynamics of human brain function are increasingly well understood at the short timescale of seconds/minutes (for example, through studies of learning) and the long timescale of years/decades (for example, through studies of development andageing), but almost nothing is known about how the human brainfunction varies across the range of days to months. This is a critical gap, because major psychiatric disorders show large fluctuations in brain function over this timescale. However, the kind of dense longitudinal phenotyping that is necessary to understand this question is extremely challenging with healthy human volunteers,who are unlikely to be sufficiently motivated to sustain frequent participation in a study over a long period. For this reason, the participation of motivated experimenters can be uniquely useful for demanding longitudinal studies. We investigated the long-range dynamics of brain function andtheir relation to a broad set of psychological and biological variables in a single healthy human (author R.A.P.) over the course of 532 days (along with several follow-up visits), representing one of the most intensive biological characterizations of a single individual ever performed (referred to hereafter as the MyConnectomestudy). The study was designed to measure the broadest possible range of human phenotypes (the phenome’3,4) to allow the widespread assessment of relations between psychological, neural and metabolic function. The results of the present study demonstrate that healthy brain function shows rich dynamics over the course of 18 months, and that these dynamics are paralleled by ongoing fluctuations in psychological and physiological function as observed in behaviour,gene expression and metabolomic measurements. These findings provide a proof of concept for the dynamic longitudinal phenotyping of individuals, which we propose will be crucial togain a better understanding of the substantial fluctuations in psychological and neural function in individuals with major psychiatric disorders.

Dataset Information

Long-term neural and physiological phenotyping of a single human.

Publications

Long-term neural and physiological phenotyping of a single human.

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