Unknown

Dataset Information

0

Encoding of long-term associations through neural unitization in the human medial temporal lobe.


ABSTRACT: Besides decades of research showing the role of the medial temporal lobe (MTL) in memory and the encoding of associations, the neural substrates underlying these functions remain unknown. We identified single neurons in the human MTL that responded to multiple and, in most cases, associated stimuli. We observed that most of these neurons exhibit no differences in their spike and local field potential (LFP) activity associated with the individual response-eliciting stimuli. In addition, LFP responses in the theta band preceded single neuron responses by ~70?ms, with the single trial phase providing fine tuning of the spike response onset. We postulate that the finding of similar neuronal responses to associated items provides a simple and flexible way of encoding memories in the human MTL, increasing the effective capacity for memory storage and successful retrieval.

SUBMITTER: Rey HG 

PROVIDER: S-EPMC6197188 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Encoding of long-term associations through neural unitization in the human medial temporal lobe.

Rey Hernan G HG   De Falco Emanuela E   Ison Matias J MJ   Valentin Antonio A   Alarcon Gonzalo G   Selway Richard R   Richardson Mark P MP   Quian Quiroga Rodrigo R  

Nature communications 20181022 1


Besides decades of research showing the role of the medial temporal lobe (MTL) in memory and the encoding of associations, the neural substrates underlying these functions remain unknown. We identified single neurons in the human MTL that responded to multiple and, in most cases, associated stimuli. We observed that most of these neurons exhibit no differences in their spike and local field potential (LFP) activity associated with the individual response-eliciting stimuli. In addition, LFP respo  ...[more]

Similar Datasets

| S-EPMC2937832 | biostudies-literature
| S-EPMC8570128 | biostudies-literature
| S-EPMC8518022 | biostudies-literature
| S-EPMC5810422 | biostudies-literature
| S-EPMC4011851 | biostudies-literature
| S-EPMC3513952 | biostudies-literature
| S-EPMC2649983 | biostudies-literature
| S-EPMC4955645 | biostudies-literature
| S-EPMC7174043 | biostudies-literature
| S-EPMC4777679 | biostudies-literature