Ontology highlight
ABSTRACT:
SUBMITTER: Fatt M
PROVIDER: S-EPMC4682208 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Fatt Michael M Hsu Karolynn K He Ling L Wondisford Fredric F Miller Freda D FD Kaplan David R DR Wang Jing J
Stem cell reports 20151119 6
The recruitment of endogenous adult neural stem cells for brain repair is a promising regenerative therapeutic strategy. This strategy involves stimulation of multiple stages of adult neural stem cell development, including proliferation, self-renewal, and differentiation. Currently, there is a lack of a single therapeutic approach that can act on these multiple stages of adult neural stem cell development to enhance neural regeneration. Here we show that metformin, an FDA-approved diabetes drug ...[more]