Ontology highlight
ABSTRACT:
SUBMITTER: Sauter D
PROVIDER: S-EPMC4682570 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Sauter Daniel D Hotter Dominik D Van Driessche Benoît B Stürzel Christina M CM Kluge Silvia F SF Wildum Steffen S Yu Hangxing H Baumann Bernd B Wirth Thomas T Plantier Jean-Christophe JC Leoz Marie M Hahn Beatrice H BH Van Lint Carine C Kirchhoff Frank F
Cell reports 20150122 4
NF-κB is essential for effective transcription of primate lentiviral genomes and also activates antiviral host genes. Here, we show that the early protein Nef of most primate lentiviruses enhances NF-κB activation. In contrast, the late protein Vpu of HIV-1 and its simian precursors inhibits activation of NF-κB, even in the presence of Nef. Although this effect of Vpu did not correlate with its ability to interact with β-TrCP, it involved the stabilization of IκB and reduced nuclear translocatio ...[more]