Ontology highlight
ABSTRACT:
SUBMITTER: Fong JJ
PROVIDER: S-EPMC4682649 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Fong Jerry J JJ Sreedhara Karthik K Deng Liwen L Varki Nissi M NM Angata Takashi T Liu Qinglian Q Nizet Victor V Varki Ajit A
The EMBO journal 20151012 22
The intracellular chaperone heat-shock protein 70 (Hsp70) can be secreted from cells, but its extracellular role is unclear, as the protein has been reported to both activate and suppress the innate immune response. Potential immunomodulatory receptors on myelomonocytic lineage cells that bind extracellular Hsp70 are not well defined. Siglecs are Ig-superfamily lectins on mammalian leukocytes that recognize sialic acid-bearing glycans and thereby modulate immune responses. Siglec-5 and Siglec-14 ...[more]