Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez E
PROVIDER: S-EPMC7904912 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Rodriguez Ernesto E Boelaars Kelly K Brown Kari K Eveline Li R J RJ Kruijssen Laura L Bruijns Sven C M SCM van Ee Thomas T Schetters Sjoerd T T STT Crommentuijn Matheus H W MHW van der Horst Joost C JC van Grieken Nicole C T NCT van Vliet Sandra J SJ Kazemier Geert G Giovannetti Elisa E Garcia-Vallejo Juan J JJ van Kooyk Yvette Y
Nature communications 20210224 1
Changes in glycosylation during tumour progression are a key hallmark of cancer. One of the glycan moieties generally overexpressed in cancer are sialic acids, which can induce immunomodulatory properties via binding to Siglec receptors. We here show that Pancreatic Ductal Adenocarcinoma (PDAC) tumour cells present an increased sialylation that can be recognized by Siglec-7 and Siglec-9 on myeloid cells. We identified the expression of the α2,3 sialyltransferases ST3GAL1 and ST3GAL4 as main cont ...[more]