Ontology highlight
ABSTRACT:
SUBMITTER: Ramos Gomes F
PROVIDER: S-EPMC4683259 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Ramos Gomes Fernanda F Romaniello Vincenzo V Sánchez Araceli A Weber Claudia C Narayanan Pratibha P Psol Maryna M Pardo Luis A LA
The Journal of biological chemistry 20151030 51
KV10.1 is a voltage-gated potassium channel expressed selectively in the mammalian brain but also aberrantly in cancer cells. In this study we identified short splice variants of KV10.1 resulting from exon-skipping events (E65 and E70) in human brain and cancer cell lines. The presence of the variants was confirmed by Northern blot and RNase protection assays. Both variants completely lacked the transmembrane domains of the channel and produced cytoplasmic proteins without channel function. In a ...[more]