Ontology highlight
ABSTRACT:
SUBMITTER: Xie XQ
PROVIDER: S-EPMC4683533 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Xie Xiang-Qun XQ Yang Peng P Zhang Yu Y Zhang Peng P Wang Liping L Ding Yahui Y Yang Ming M Tong Qin Q Cheng Haizi H Ji Qing Q McGuire Terence T Yuan Weiping W Cheng Tao T Gao Yingdai Y
Scientific reports 20151218
Hematopoietic stem cells (HSCs) have emerged as promising therapeutic cell sources for high-risk hematological malignancies and immune disorders. However, their clinical use is limited by the inability to expand these cells ex vivo. Therefore, there is an urgent need to identify specific targets and effective probes that can expand HSCs. Here we report a novel class of INK4C (p18(INK4C) or p18) small molecule inhibitors (p18SMIs), which were initially found by in silico 3D screening. We identifi ...[more]