Ontology highlight
ABSTRACT:
SUBMITTER: Reddy BG
PROVIDER: S-EPMC4684441 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Reddy Bharat G BG Dai Qun Q McNicholas Carmel M CM Fuller Catherine M CM Kappes John C JC DeLucas Lawrence J LJ
Protein expression and purification 20150921
The epithelial sodium channel (ENaC) plays a critical role in maintaining Na(+) homeostasis in various tissues throughout the body. An understanding of the structure of the ENaC subunits has been developed from homology modeling based on the related acid sensing ion channel 1 (ASIC1) protein structure, as well as electrophysiological approaches. However, ENaC has several notable functional differences compared to ASIC1, thereby providing justification for determination of its three-dimensional s ...[more]