Ontology highlight
ABSTRACT:
SUBMITTER: Pratt EP
PROVIDER: S-EPMC4684454 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Pratt Evan P S EP Salyer Amy E AE Guerra Marcy L ML Hockerman Gregory H GH
Molecular and cellular endocrinology 20151003
We previously reported that INS-1 cells expressing the intracellular II-III loop of the L-type Ca(2+) channel Cav1.2 (Cav1.2/II-III cells) are deficient in Ca(2+)-induced Ca(2+) release (CICR). Here we show that glucose-stimulated ERK 1/2 phosphorylation (GSEP) is slowed and reduced in Cav1.2/II-III cells compared to INS-1 cells. This parallels a decrease in glucose-stimulated cAMP accumulation (GS-cAMP) in Cav1.2/II-III cells. Influx of Ca(2+) via L-type Ca(2+) channels and CICR play roles in b ...[more]